E-Fate

We offer deter­mi­na­tion of route & rate of degra­da­tion under biotic and abiotic condi­tions in a wide variety of matrices:

In addi­tion we offer:

  • GLP- & Non-GLP-conform studies following inter­na­tional guide­lines (US-EPA OPPTS/OCSPP, OECD, JMAFF, REACH, EU, etc.)
  • 14C-tracer and non-labeled studies
  • USDA Permit to conduct studies in foreign & restricted soils or water/​sediment systems
  • Flex­i­bility of exper­i­mental set-up: From benchtop incu­ba­tors to walk-in, temper­a­ture-controlled room
  • State-of-the-art iden­ti­fi­ca­tion of degra­da­tion prod­ucts & metabo­lites via variety of high-reso­lu­tion mass spec­tro­scopic instru­ments (i.e., QTOF MS connected to HPLC or UHPLC & Capil­lary Elec­trophoresis (CE and CZE-MS-TOF)
  • Open-air envi­ron­mental dissi­pa­tion studies with radio­tracers (14C)
  • Sterile soil & water/​sediment studies
  • Adsorption/​desorption in soil, sedi­ment & sludge; aged sorp­tion; column leaching/​aged leaching
  • Unique adap­ta­tion for non-guide­line studies

Biodegradation

We offer a variety of exper­i­mental set-up options to study the decom­po­si­tion of organic substances under envi­ron­men­tally rele­vant conditions:

  • GLP- & Non-GLP-conform studies following inter­na­tional guide­lines (US-EPA OPPTS/OCSPP, OECD, ECHA, etc.)
  • Possi­bility to conduct biodegra­da­tion tests using radio­tracer (14C) or non-labeled set-up
  • Different sources of inoculum are possible, for example, acti­vated sludge, sewage efflu­ents, natural surface waters & soils
  • Possi­bility to use inoculum from sources outside the USA based on USDA Permit to conduct studies in foreign & restricted soils or water/​sediment systems
  • Ready Biodegrad­ability testing following tiered approach: From inoc­u­lated media to real­istic soil/​water/​sediment set-up
  • Flex­i­bility of exper­i­mental set-up: From benchtop incu­ba­tors to walk-in, temper­a­ture-controlled room
  • State-of-the-art iden­ti­fi­ca­tion of degra­da­tion prod­ucts & metabo­lites via variety of mass spec­tro­scopic instru­ments (TOF & triple quad MS connected to HPLC, UHPLC or Capil­lary Elec­trophoresis (CE)
  • Unique adap­ta­tion for non-guide­line studies, for example, field level testing via modi­fied litter bag tests at our in-life facility
  • OECD 301 Ready Biodegrad­ability: 301F, Mano­metric Respirometry
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