Environmental Fate Studies

We offer determination of route & rate of degradation under biotic and abiotic conditions in a wide variety of matrices:

• OECD 106 – Adsorption/Desorption
• OECD 111 – Aqueous Hydrolysis
• OECD 301 – Ready Biodegradability: 301F, Manometric Respirometry
• OECD 303 – Simulation test, Activated Sludge Units
• OECD 304A – Inherent Biodegradability in Soil
• OECD 305 – Bioaccumulation in Fish: Aqueous and Dietary Exposure
• OECD 307 – Soil Simulation Test: Aerobic and Anaerobic Soil Metabolism
• OECD 308 – Freshwater / Sediment Simulation Test: Aerobic & Anaerobic Aquatic Metabolism
• OECD 309 – Fresh Water Simulation Test: Aerobic Mineralization in Surface Water – Simulation Biodegradation Test
• OECD 312 – Column Leaching and Aged Column Leaching
• OECD 316 – Photo-transformation of Chemicals in Water-Direct Photolysis
• OECD draft – Photo-transformation on Chemicals on Soil Surfaces
• OECD 507 – High Temperature Hydrolysis
• OSCPP 835.6100 – Field Dissipation

In addition we offer:

• GLP- & Non-GLP-conform studies following international guidelines (US-EPA OPPTS/OCSPP, OECD, JMAFF, REACH, EU, etc.)
• 14C-tracer and non-labeled studies
• USDA Permit to conduct studies in foreign & restricted soils or water/sediment systems
• Flexibility of experimental set-up: From benchtop incubators to walk-in, temperature-controlled room
• State-of-the-art identification of degradation products & metabolites via variety of high-resolution mass spectroscopic instruments (i.e., QTOF MS connected to HPLC or UHPLC & Capillary Electrophoresis (CE and CZE-MS-TOF)
• Open-air environmental dissipation studies with radiotracers (14C)
• Sterile soil & water/sediment studies
• Adsorption/desorption in soil, sediment & sludge; aged sorption; column leaching/aged leaching
• Unique adaptation for non-guideline studies

We offer a variety of experimental set-up options to study the decomposition of organic substances under environmentally relevant conditions:

• GLP- & Non-GLP-conform studies following international guidelines (US-EPA OPPTS/OCSPP, OECD, ECHA, etc.)
• Possibility to conduct biodegradation tests using radiotracer (14C) or non-labeled set-up
• Different sources of inoculum are possible, for example, activated sludge, sewage effluents, natural surface waters & soils
• Possibility to use inoculum from sources outside the USA based on USDA Permit to conduct studies in foreign & restricted soils or water/sediment systems
• Ready Biodegradability testing following tiered approach: From inoculated media to realistic soil/water/sediment set-up
• Flexibility of experimental set-up: From benchtop incubators to walk-in, temperature-controlled room
• State-of-the-art identification of degradation products & metabolites via variety of mass spectroscopic instruments (TOF & triple quad MS connected to HPLC, UHPLC or Capillary Electrophoresis (CE)
• Unique adaptation for non-guideline studies, for example, field level testing via modified litter bag tests at our in-life facility
• OECD 301 Ready Biodegradability: 301F, Manometric Respirometry