Environmental Fate Studies

We offer deter­mi­na­tion of route & rate of degra­da­tion under biotic and abiotic condi­tions in a wide variety of matrices:

• OECD 106 – Adsorption/​Desorption
• OECD 111 – Aqueous Hydrolysis
• OECD 301 – Ready Biodegrad­ability: 301F, Mano­metric Respirometry
• OECD 303 – Simu­la­tion test, Acti­vated Sludge Units
• OECD 304A – Inherent Biodegrad­ability in Soil
• OECD 305 – Bioac­cu­mu­la­tion in Fish: Aqueous and Dietary Exposure
• OECD 307 – Soil Simu­la­tion Test: Aerobic and Anaer­obic Soil Metabolism
• OECD 308 – Fresh­water / Sedi­ment Simu­la­tion Test: Aerobic & Anaer­obic Aquatic Metabolism
• OECD 309 – Fresh Water Simu­la­tion Test: Aerobic Miner­al­iza­tion in Surface Water – Simu­la­tion Biodegra­da­tion Test
• OECD 312 – Column Leaching and Aged Column Leaching
• OECD 316 – Photo-trans­for­ma­tion of Chem­i­cals in Water-Direct Photolysis
• OECD draft – Photo-trans­for­ma­tion on Chem­i­cals on Soil Surfaces
• OECD 507 – High Temper­a­ture Hydrolysis
• OSCPP 835.6100 – Field Dissipation

In addi­tion we offer:

• GLP- & Non-GLP-conform studies following inter­na­tional guide­lines (US-EPA OPPTS/OCSPP, OECD, JMAFF, REACH, EU, etc.)
• 14C-tracer and non-labeled studies
• USDA Permit to conduct studies in foreign & restricted soils or water/​sediment systems
• Flex­i­bility of exper­i­mental set-up: From benchtop incu­ba­tors to walk-in, temper­a­ture-controlled room
• State-of-the-art iden­ti­fi­ca­tion of degra­da­tion prod­ucts & metabo­lites via variety of high-reso­lu­tion mass spec­tro­scopic instru­ments (i.e., QTOF MS connected to HPLC or UHPLC & Capil­lary Elec­trophoresis (CE and CZE-MS-TOF)
• Open-air envi­ron­mental dissi­pa­tion studies with radio­tracers (14C)
• Sterile soil & water/​sediment studies
• Adsorption/​desorption in soil, sedi­ment & sludge; aged sorp­tion; column leaching/​aged leaching
• Unique adap­ta­tion for non-guide­line studies

We offer a variety of exper­i­mental set-up options to study the decom­po­si­tion of organic substances under envi­ron­men­tally rele­vant conditions:

• GLP- & Non-GLP-conform studies following inter­na­tional guide­lines (US-EPA OPPTS/OCSPP, OECD, ECHA, etc.)
• Possi­bility to conduct biodegra­da­tion tests using radio­tracer (14C) or non-labeled set-up
• Different sources of inoculum are possible, for example, acti­vated sludge, sewage efflu­ents, natural surface waters & soils
• Possi­bility to use inoculum from sources outside the USA based on USDA Permit to conduct studies in foreign & restricted soils or water/​sediment systems
• Ready Biodegrad­ability testing following tiered approach: From inoc­u­lated media to real­istic soil/​water/​sediment set-up
• Flex­i­bility of exper­i­mental set-up: From benchtop incu­ba­tors to walk-in, temper­a­ture-controlled room
• State-of-the-art iden­ti­fi­ca­tion of degra­da­tion prod­ucts & metabo­lites via variety of mass spec­tro­scopic instru­ments (TOF & triple quad MS connected to HPLC, UHPLC or Capil­lary Elec­trophoresis (CE)
• Unique adap­ta­tion for non-guide­line studies, for example, field level testing via modi­fied litter bag tests at our in-life facility
• OECD 301 Ready Biodegrad­ability: 301F, Mano­metric Respirometry